The main theme of our research program is to elucidate the interactions of biologically important molecules in complex molecular assemblies. To pursue this research direction, we are using a highly interdisciplinary approach, which builds on state-of-the-art engineered supramolecular assemblies paired with high-resolution imaging techniques. Specifically, we have developed four complementary research directions: (i) Structure and dynamics of polymer-tethered phospholipid membranes; (ii) Biophysical mechanisms of protein recruitment to raft domains; (iii) Biomimetic cell substrates; and (iv) Fluorescent nanoparticle imaging probes. The research on membrane biophysics and biomimetic cell substrates is funded by the National Science Foundation (NSF) through the Divisions of Molecular and Cellular Bioscience (MCB) and Materials Research (DMR). Our research on nanoparticle imaging probes has been supported by NIH.

pic1  pic2Structure and Dynamics of Polymer-Tethered Membranes

pic3 pic4Biophysical Mechanisms of Protein Recruitment to Raft Domains

pic3  pic4Biomimetic Cell Substrates

pic7  pic4Fluorescent Nanoparticle Imaging Probes